Related Experiment Video
Updated: Aug 10, 2026

08:51
Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Phospholipase C activity in normal rat mammary tissues and in DMBA-induced rat mammary tumors
Abstract:
Employing phosphatidylinositol as the substrate, phospholipase C (PLC) activity was measured in various cellular fractions derived from DMBA-induced rat mammary tumors and mammary tissues from 12-14 day pregnant rats. In the 2,000g pellet, 10,000g pellet, 100,000g pellet and 100,000g supernatant fractions, PLC activity was more than 5 fold higher in the fractions derived from the neoplastic tissues. This was true whether PLC activity was expressed on the basis of protein content or 5' nucleotidase activities.

