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Galectin-3 is associated with arterial stiffness among hemodialysis patients

Qi Zhang1,2, Kanhua Yin3, Mingli Zhu2

  • 1Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, PR China.

Biomarkers in Medicine
|February 28, 2019
PubMed

Insights

Galectin-3 is linked to arterial stiffness in hemodialysis patients. This finding suggests galectin-3 may be a biomarker for cardiovascular risk in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Arterial stiffness is a significant cardiovascular risk factor in patients undergoing hemodialysis.
  • Galectin-3, a protein involved in fibrosis and inflammation, has emerged as a potential biomarker for cardiovascular disease.

Purpose of the Study:

  • To investigate the association between serum galectin-3 levels and arterial stiffness in patients receiving hemodialysis.
  • To determine if galectin-3 is an independent predictor of arterial stiffness, even after accounting for traditional cardiovascular risk factors.

Main Methods:

  • A cross-sectional study involving 311 hemodialysis patients.
  • Arterial stiffness was assessed using pulse-wave velocity (PWV > 10 m/s).
  • Serum galectin-3 concentrations were measured and correlated with clinical parameters and cardiovascular risk factors.

Main Results:

  • Galectin-3 levels were associated with dialysis vintage, calcium, phosphorus, and low-density lipoprotein.
  • After adjusting for multiple cardiovascular risk factors, galectin-3 remained independently associated with pulse-wave velocity (partial r = 0.130; p = 0.035).
  • This association persisted even after further adjustment for mean arterial pressure and single-pool Kt/V (partial r = 0.139; p = 0.014).

Conclusions:

  • Serum galectin-3 is independently associated with arterial stiffness in hemodialysis patients.
  • Galectin-3 may serve as a valuable biomarker for assessing cardiovascular risk and arterial stiffness in this vulnerable population.

Keywords:
arterial stiffnessgalectin-3hemodialysispulse-wave velocity

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