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Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia

Leila Haghighat1, Costin N Ionescu2, Christopher J Regan2

  • 11 Department of Internal Medicine, Yale New Haven Hospital, New Haven, CT, USA     .

Vascular and Endovascular Surgery
|February 28, 2019
PubMed

Insights

Critical limb ischemia (CLI) is a severe condition lacking treatment options. This review covers CLI pathophysiology, molecular therapies, and new imaging techniques for assessing treatment efficacy.

Area of Science:

  • Vascular biology
  • Translational medicine
  • Regenerative medicine

Background:

  • Critical limb ischemia (CLI) is a severe vascular disease with limited treatment options.
  • Many CLI patients are poor surgical candidates, necessitating alternative therapies.
  • Recent research focuses on molecular therapies to address CLI's pathophysiology.

Purpose of the Study:

  • To provide an overview of macrovascular and microvascular changes in CLI.
  • To summarize randomized clinical trials of molecular therapies for CLI.
  • To discuss novel imaging modalities for evaluating therapeutic efficacy.

Main Methods:

  • Review of pathophysiology of critical limb ischemia.
  • Summary of randomized clinical controlled trials involving molecular therapies.
  • Discussion of emerging imaging techniques for CLI assessment.

Main Results:

  • CLI involves impaired angiogenesis, vasculogenesis, and arteriogenesis.
  • Several molecular therapies have been investigated in clinical trials.
  • Novel imaging modalities are under development to assess treatment response.

Conclusions:

  • Understanding CLI pathophysiology is crucial for developing effective treatments.
  • Molecular therapies show promise for CLI patients, particularly those unsuitable for surgery.
  • Advanced imaging will be essential for validating new CLI therapies.
Keywords:
critical limb ischemiamolecular therapytranslational medicine

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