Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Valproate and myoclonus.

A G Chapman

    Advances in Neurology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Valproate

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Brain regional amino acid levels in seizure susceptible rats: Changes related to sound-induced seizures.

    Neurochemistry international·2010
    Same author

    Temperature response of oxygen uptake in brain mitochondria from normal and ischemic rats.

    Neurochemistry international·2010
    Same author

    Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.

    European journal of pharmacology·2001
    Same author

    Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795).

    Neuropharmacology·2001
    Same author

    Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.

    Neuropharmacology·2001
    Same author

    The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice.

    Neuroscience letters·2001
    Same journal

    Future and alternative therapies in Tourette syndrome.

    Advances in neurology·2006
    Same journal

    Behavioral neurosurgery.

    Advances in neurology·2006
    Same journal

    Behavior therapy: other interventions for tic disorders.

    Advances in neurology·2006
    Same journal

    Behavioral treatments for tic suppression: habit reversal training.

    Advances in neurology·2006
    Same journal

    Treatment of aggression in Tourette syndrome.

    Advances in neurology·2006
    Same journal

    Treatment of co-morbid obsessive compulsive disorder, mood, and anxiety disorders.

    Advances in neurology·2006
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Biochemistry

    Background:

    • Valproate is a widely used antiepileptic drug with an unknown mechanism of action.
    • Several neurotransmitter systems are known to be modulated by valproate.

    Purpose of the Study:

    • To investigate the effects of valproate on various neurotransmitter systems.
    • To elucidate the potential mechanisms underlying valproate's anticonvulsant activity.

    Main Methods:

    • Administration of valproate to rodents and analysis of neurotransmitter levels (serotonin, glycine, GABA, aspartate).
    • Assessment of valproate's effects on enzyme activity (hepatic glycine cleavage, GABA-T, SSADH).
    • Evaluation of valproate's impact on neuronal firing and neurotransmitter uptake/release/binding.

    Main Results:

    • Valproate elevated brain serotonin precursor and metabolite levels but anticonvulsant action was preserved after serotonin depletion.
    • Valproate increased urinary and plasma glycine levels and inhibited hepatic glycine cleavage, but did not affect cerebral glycine levels or action.
    • Valproate increased brain GABA levels, inhibited GABA-metabolizing enzymes, and augmented GABA's inhibitory neuronal effects. It also decreased cerebral aspartate levels in a dose-dependent manner, correlating with anticonvulsant potency.

    Conclusions:

    • Valproate's anticonvulsant effects are not solely mediated by serotonin.
    • Valproate's mechanism involves modulation of inhibitory neurotransmitters like GABA and potentially excitatory neurotransmitters like aspartate.
    • Valproate's multifaceted actions on neurotransmitter systems contribute to its therapeutic efficacy in epilepsy.

    Related Experiment Videos