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Updated: Jan 28, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
[Renal hemosiderosis following mechanical hemolysis: An original case report]
Julie Zettl1, Philippe Mirgaine1, Bernadette Aymard2
1Service de néphrologie dialyse, CHR de Metz-Thionville, 57085 Metz cedex 03, France.
Abstract:
Renal hemosiderosis is a rare cause of acute kidney injury, but it can also lead to chronic kidney failure. We report here the case of a 73-year-old patient with acute kidney caused by a massive hemosiderosis following the proximal disinsertion of a prosthesis of the ascendant aorta with chronic aortic dissection. The kidney biopsy revealed the diagnosis, showing massive iron deposits inside the proximal tubules, especially with Perls staining and also diffuse hematic casts in the lumen of the tubules. Pathophysiology of hemosiderosis is well described, as well as protective mechanisms. This case report is one of the numerous different causes of renal hemosiderosis that can be related to genetic, infectious or mechanical hemolysis.
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