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Updated: Jan 28, 2026
07:18
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
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Right-angled vessels in macular telangiectasia type 2
Simone Tzaridis1, Tjebo Heeren2,3, Clarissa Mai4
1Department of Ophthalmology, University Hospital Bonn, Bonn, Germany Simone.Mueller@ukb.uni-bonn.de.
The British Journal of Ophthalmology
|February 28, 2019
Summary
Right-angled vessels (RAVs) play a key role in macular telangiectasia type 2 (MacTel) progression, appearing early and contributing to neovascularization. These vessels connect directly to neovascular complexes, highlighting their significance in disease development.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Macular telangiectasia type 2 (MacTel) is a progressive retinal disease.
- The role of specific vascular abnormalities in MacTel progression is not fully understood.
Purpose of the Study:
- To evaluate the role of right-angled vessels (RAVs) in the progression of macular telangiectasia type 2 (MacTel).
Main Methods:
- Examined 100 eyes of 52 MacTel patients and 52 eyes of 26 controls.
- Utilized fundus photography, SD-OCT, OCT-A, and FFA to assess RAVs and neovascularizations (NVs).
- Graded disease stages and analyzed RAVs' origin, course, and association with NVs.
Main Results:
- RAVs were detected in early MacTel stages (1-2) using OCT-A and tracked through retinal layers.
- RAVs originated from both arterial and venous sources and formed outer retinal anastomoses.
- RAVs were present in all neovascular MacTel eyes, directly connecting to and changing with NV formation.
Conclusions:
- RAVs are involved in MacTel progression from early stages.
- RAVs play a significant role in the development of secondary neovascularizations in MacTel.
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