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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
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Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897
Ka-Shing Cheung1, Lijia Chen1, Esther W Chan2
1Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Gut
|February 28, 2019
Summary
Statin use may reduce the risk of postcolonoscopy colorectal cancer (PCCRC), especially for proximal tumors. This finding suggests a potential benefit of statins in preventing interval colorectal cancers.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Postcolonoscopy colorectal cancer (PCCRC) accounts for up to 9% of all colorectal cancers (CRCs).
- Statins are known to be associated with a reduced risk of CRC.
- The potential benefit of statins in reducing PCCRC risk requires investigation.
Purpose of the Study:
- To investigate the association between statin use and the risk of developing PCCRC.
- To determine if statin use impacts the risk of proximal versus distal PCCRC.
Main Methods:
- Retrospective cohort study using a Hong Kong electronic healthcare database (2005-2013).
- Included patients aged 40+ who underwent colonoscopy; excluded those with prior CRC, IBD, colectomy, or CRC within 6 months.
- Defined statin use as ≥90 days prior to index colonoscopy; analyzed PCCRC diagnosed 6-36 months post-colonoscopy using propensity score matching.
Main Results:
- Out of 187,897 eligible subjects, 854 (0.45%) were diagnosed with PCCRC within 3 years.
- Statin use was significantly associated with a lower risk of PCCRC (SHR: 0.72; p=0.018).
- Statin use showed a stronger association with reduced risk for proximal PCCRC (SHR: 0.50; p=0.022) compared to distal PCCRC (SHR: 0.80; p=0.160).
Conclusions:
- Statin use is associated with a reduced risk of postcolonoscopy colorectal cancer.
- The protective effect of statins appears more pronounced for proximal PCCRC.
- Older patients, women, and those without diabetes or polyps may benefit more from statins.
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