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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
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Related Experiment Video

Updated: Jan 28, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking

Tingting Sun1, Zihua Song1, Yanghua Tian2

  • 1Hefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.

Proceedings of the National Academy of Sciences of the United States of America
|February 28, 2019
PubMed
Summary

Researchers identified a specific brain circuit, the basolateral amygdala to medial prefrontal cortex (BLA-mPFC) pathway, that drives excessive checking behaviors in obsessive-compulsive disorder (OCD). Modulating this circuit offers potential therapeutic targets for OCD.

Keywords:
BLAOCD checking symptomsmPFCneural circuit

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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • Obsessive-compulsive disorder (OCD) impacts 1-3% of the global population, yet its underlying neural mechanisms, particularly for excessive checking, remain unclear.
  • Understanding the specific neural circuits involved in OCD symptoms is crucial for developing targeted treatments.

Purpose of the Study:

  • To elucidate the neural circuitry responsible for excessive checking behaviors in a mouse model of obsessive-compulsive disorder (OCD).
  • To investigate the role of the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) in regulating repetitive checking behaviors.

Main Methods:

  • Utilized viral neuronal tracing in mice to map projections from glutamatergic neurons in the BLA (BLAGlu) to mPFC glutamate (mPFCGlu) and GABA (mPFCGABA) neurons.
  • Developed a mouse model exhibiting repetitive checking behaviors induced by quinpirole.
  • Employed optical and chemogenetic manipulations to alter the activity of the identified BLA-mPFC circuit.
  • Verified findings using mouse functional magnetic resonance imaging (fMRI) to assess BLA-mPFC functional connectivity.

Main Results:

  • Identified a BLAGlu→mPFCGABA→Glu circuit where BLAGlu neurons project to mPFCGABA neurons, which in turn modulate mPFCGlu neurons.
  • Observed decreased glutamatergic microcircuit activity in the mPFC of the OCD mouse model, associated with enhanced BLAGlu inputs.
  • Demonstrated that manipulating this circuit, either optically or chemogenetically, effectively restored normal behavioral responses.
  • Observed increased functional connectivity between the BLA and mPFC in OCD mice via fMRI.

Conclusions:

  • Defined a novel BLAGlu→mPFCGABA→Glu circuit critical for controlling excessive checking symptoms in obsessive-compulsive disorder.
  • This circuit represents a potential therapeutic target for interventions aimed at reducing checking behaviors in OCD.
  • The findings provide a deeper understanding of the neurobiological underpinnings of OCD-related repetitive behaviors.