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Association Between the Lipid Profile and Renal Dysfunction in the Heart Failure Patients

Hong Zhang1, Shuang Shi2, Xiu-Juan Zhao3

  • 1Department of Neurology, People's Hospital of Shaanxi Province, Xi'an, China.

Kidney & Blood Pressure Research
|February 28, 2019
PubMed

Insights

In heart failure patients, high-density lipoprotein-cholesterol (HDL-C) was the sole lipid marker linked to renal dysfunction. This finding is crucial for managing heart failure with chronic kidney disease (CKD).

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Lipidology

Background:

  • Heart failure (HF) frequently co-occurs with chronic kidney disease (CKD), increasing hospitalization and mortality risks.
  • The relationship between lipid profiles and renal dysfunction in HF patients remains under-explored.

Purpose of the Study:

  • To investigate the association between various lipid parameters and renal dysfunction in hospitalized patients with heart failure.

Main Methods:

  • A cohort of 336 hospitalized heart failure patients (LVEF ≤45%, NYHA class II-IV) was analyzed.
  • Renal dysfunction was defined as estimated glomerular filtration rate (eGFR) < 90 mL/min·1.73 m2.
  • Logistic regression was employed to assess the association between lipid profiles and renal dysfunction, adjusting for confounders.

Main Results:

  • Over half (54.2%) of the patients exhibited renal dysfunction.
  • High-density lipoprotein-cholesterol (HDL-C) was significantly associated with renal dysfunction (OR=0.119, P=0.003) after adjusting for multiple clinical and laboratory variables.
  • Total cholesterol, triglycerides, LDL-C, and apolipoprotein B showed no significant correlation with eGFR.

Conclusions:

  • High-density lipoprotein-cholesterol (HDL-C) is the only lipid profile component significantly associated with renal dysfunction in hospitalized heart failure patients.
  • These findings highlight the importance of HDL-C in the context of cardiorenal syndrome.
Abstract

Keywords:
EGFRHDL-CHeart failureLipidRenal dysfunction

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