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Raman Spectroscopy: Overview01:20

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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Updated: Jan 28, 2026

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Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy.

Yuying Zhang1, Xue Mi1, Xiaoyue Tan1

  • 1School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, 300071 Tianjin, China.

Theranostics
|February 28, 2019
PubMed
Summary
This summary is machine-generated.

Liquid biopsy offers a non-invasive alternative to traditional tissue biopsy for cancer detection. Surface-enhanced Raman spectroscopy (SERS) shows great promise for analyzing circulating cancer markers for early screening and monitoring.

Keywords:
circulating tumor DNAcirculating tumor cellexosomeliquid biopsysurface-enhanced Raman spectroscopy

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Oncology

Background:

  • Traditional tissue biopsy has limitations in capturing tumor heterogeneity and evolution.
  • Liquid biopsy, analyzing circulating cancer markers in body fluids, offers a promising non-invasive approach.
  • Surface-enhanced Raman spectroscopy (SERS) provides high sensitivity and specificity for biomolecule detection.

Purpose of the Study:

  • To review recent advancements in SERS-based techniques for liquid biopsy.
  • To highlight the application of SERS in detecting various circulating cancer markers.
  • To discuss the clinical translation challenges of SERS platforms.

Main Methods:

  • Review of SERS principles and mechanisms.
  • Analysis of SERS-based detection of circulating tumor cells, exosomes, ctDNA, microRNAs, and proteins.
  • Inclusion of SERS analysis of bulk body fluids for cancer diagnosis.

Main Results:

  • SERS demonstrates high sensitivity, specificity, and multiplexing capacity for cancer marker detection.
  • SERS enables non-invasive cancer screening, progression monitoring, and therapy response assessment.
  • Various SERS-based platforms show potential for clinical application.

Conclusions:

  • SERS is a powerful technique for liquid biopsy, offering significant advantages over traditional methods.
  • Further development and validation are needed to overcome challenges in clinical translation.
  • SERS holds great potential for revolutionizing cancer diagnostics and management.