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Updated: May 5, 2026

Generation of Murine Monoclonal Antibodies by Hybridoma Technology
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Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

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Tailor-made monoclonal antibodies

R A DePinho, L B Feldman, M D Scharff

    Annals of Internal Medicine
    |February 1, 1986
    PubMed

    Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

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