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Updated: Jan 28, 2026
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Fecal microbiota transplantation research output from 2004 to 2017: a bibliometric analysis
Yan Li1,2, Ziyuan Zou3, Xiaohui Bian2
1Department of General Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Background:
Fecal microbiota transplantation (FMT) is an emerging therapy against Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). Although the therapy has gained prominence, there has been no bibliometric analysis of FMT.
Methods:
Studies published from 2004 to 2017 were extracted from the Science Citation Index Expanded. Bibliometric analysis was used to evaluate the number or cooperation network of publications, countries, citations, references, journals, authors, institutions and keywords.
Results:
A total of 796 items were included, showing an increasing trend annually. Publications mainly came from 10 countries, led by the US (n = 363). In the top 100 articles ranked by the number of citations (range 47-1,158), American Journal of Gastroenterology (2017 IF = 10.231) took the top spot. The co-citation network had 7 co-citation clusters headed by 'recurrent Clostridium difficile infection'. The top 7 keywords with the strongest citation bursts had three parts, 'microbiota', ' diarrhea ', and 'case series'. All keywords were divided into four domains, 'disease', 'nosogenesis', 'trial', and 'therapy'.
Conclusions:
This study shows the research performance of FMT from 2004 to 2017 and helps investigators master the trend of FMT, which is also an ongoing hotspot of research.
Insights
Fecal microbiota transplantation (FMT) research shows a significant annual increase. This bibliometric analysis highlights key publications, countries, and keywords in FMT from 2004-2017.
Area of Science:
- Gastroenterology and Microbiology
- Bibliometric Analysis
- Therapeutic Research
Background:
- Fecal microbiota transplantation (FMT) is an emerging therapy for Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD).
- Despite its growing prominence, a comprehensive bibliometric analysis of FMT research was lacking.
- This study addresses this gap by analyzing the research landscape of FMT.
Purpose of the Study:
- To conduct a bibliometric analysis of fecal microbiota transplantation (FMT) research.
- To evaluate publication trends, international collaboration, and influential works in the field from 2004 to 2017.
- To identify key research areas and emerging themes within FMT.
Main Methods:
- A systematic extraction of studies published between 2004 and 2017 from the Science Citation Index Expanded.
- Application of bibliometric analysis to assess publication output, international cooperation, citation networks, and keyword trends.
- Evaluation of journals, authors, institutions, and keywords contributing to the FMT research landscape.
Main Results:
- A total of 796 publications were identified, demonstrating a consistent annual increase in research output.
- The United States led in publications (n=363), with the American Journal of Gastroenterology publishing highly cited articles.
- Co-citation analysis revealed clusters around 'recurrent Clostridium difficile infection', and keywords like 'microbiota', 'diarrhea', and 'case series' showed significant citation bursts.
Conclusions:
- The study provides a comprehensive overview of FMT research performance from 2004 to 2017.
- Findings help researchers understand current trends and identify key areas for future investigation in FMT.
- Fecal microbiota transplantation remains a dynamic and significant area of ongoing scientific inquiry.
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