Related Experiment Video

Updated: Jan 28, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.2K

Relations between approved platinum drugs and non-coding RNAs in mesothelioma

Bernhard Biersack1

  • 1Organic Chemistry Laboratory, University of Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany.

Non-Coding RNA Research
|February 28, 2019
PubMed

Keywords:
ABC, ATP-binding cassetteAKBA, 3-acetyl-11-keto-β-boswellic acidAKI, acute kidney injuryAnticancer drugsBcl-2, B-cell lymphoma 2CAF, cancer-associated fibroblastCBDCA, cyclobutane-1,1-dicarboxylateCarboplatinCisplatinDADS, diallyl sulfideDHA, docosahexaenoic acidDIM, 3,3′-diindolylmethaneDMPM, diffuse malignant peritoneal mesotheliomaEGCG, epigallocatechin-3-gallateEMT, epithelial-mesenchymal transitionHOTAIR, HOX transcript antisense RNAI3C, indole-3-carbinolLong non-coding RNAMALAT1, metastasis-associated lung adenocarcinoma transcript 1MPM, malignant pleural mesotheliomaMRP1, multidrug resistance protein 1MesotheliomaMicroRNANSCLC, non-small cell lung cancerNaB, sodium butyratePDCD4, programmed cell death 4PEG, polyethylene glycolePEITC, phenethylisothiocyanatePTEN, phosphatase and tensin homologRA, retinoic acidSAHA, suberoylanilide hydroxamic acidSFN, sulforaphaneTNBC, triple-negative breast cancerTSA, trichostatin A

More Related Videos

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

8.8K
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy12:03

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

8.2K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
257
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.6K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
Nursing Code of Ethics01:29

Nursing Code of Ethics

The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.5K