Related Experiment Video
Updated: Jan 28, 2026

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength-modulated differential
Xinxin Guo1, Di Zhang1, Khashayar Shojaei-Asanjan1
1Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), University of Toronto, Toronto, Ontario, Canada.
Abstract:
We present a noninvasive and noncontacting biosensor using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR) to monitor blood glucose concentration (BGC) through interstitial fluid (ISF) probing in human middle fingers. WM-DPTR works in the interference-free mid-infrared range with differential wavelengths at the peak and baseline of the fundamental glucose molecule absorption band, giving rise to high glucose sensitivity and specificity. In vivo WM-DPTR measurements and simultaneous finger pricking BGC reference measurements were performed on diabetic and nondiabetic volunteers during oral glucose tolerance testing. The measurement results demonstrated high resolution and large dynamic range (~80 deg) change in phase signal in the normal-to-hyperglycemia BGC range (5 mmol/L to higher than 33.2 mmol/L), which were supported by negative control measurements. The immunity to temperature variation of WM-DPTR yields precise and accurate noninvasive glucose measurements in the ISF.
More Related Videos
10:35Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
11:53Derivation of Highly Purified Cardiomyocytes from Human Induced Pluripotent Stem Cells Using Small Molecule-modulated Differentiation and Subsequent Glucose Starvation
Published on: March 18, 2015
Related Concept Videos
The de Broglie Wavelength
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
The Fluid Mosaic Model
Muscles of the Forearm that Move the Hand and Fingers
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Glucose Absorption Into the Small Intestine