Related Experiment Video
Updated: Jan 28, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Reduced artifacts and improved diagnostic value of 640-slice computed tomography in patients with cardiac pacemakers
Guoquan Cao1, Weijian Chen1, Kehua Pan1
11 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Insights
640-slice computed tomography (CT) is more effective than 64-slice CT for diagnosing coronary artery disease in pacemaker patients, significantly reducing artifacts and improving lesion detection.
Area of Science:
- Cardiovascular Imaging
- Medical Technology
- Radiology
Background:
- Pacemakers can cause artifacts in coronary computed tomography angiography (CTCA).
- Accurate diagnosis of coronary artery disease (CAD) is challenging in pacemaker patients.
Purpose of the Study:
- To compare the diagnostic feasibility of 640-slice CTCA versus 64-slice CTCA in patients with pacemakers.
- To evaluate the impact of CT technology on artifact reduction and lesion detectability.
Main Methods:
- A comparative study involving 45 patients in the 64-slice group and 50 patients in the 640-slice group.
- All patients had pacemakers and suspected or known CAD.
- Coronary artery segments were assessed using the American Heart Association 15-segment model.
Main Results:
- The 640-slice CT group showed significantly lower moderate/severe artifact incidence (7.27% vs. 32.17%) and higher diagnosable rates (98.91% vs. 94.19%).
- Artifacts were more common in patients with heart rates >65 bpm and heart arrhythmia in the 64-slice group.
- Higher heart rates and arrhythmia were associated with increased artifact incidence in the 64-slice group.
Conclusions:
- 640-slice CTCA demonstrates superior performance in diagnosing coronary lesions in pacemaker patients compared to 64-slice CTCA.
- This improved efficacy is attributed to the reduction of moderate and severe artifacts.
- 640-slice CT is particularly beneficial for patients with elevated heart rates or arrhythmias.
Objective:
The aim of this study was to compare the feasibility of 640-slice with 64-slice computed tomography (CT) coronary angiography for diagnosing coronary lesions in patients with pacemakers.
Methods:
Forty-five and 50 patients with pacemakers and with suspected or known coronary artery disease underwent 64-slice (64 group) and 640-slice (640 group) CT scans, respectively. All segments of the vessels were evaluated according to the 15-segment model recommended by the American Heart Association.
Results:
The incidence of moderate or severe artifacts was significantly lower (7.27% vs. 32.17%) and the diagnosable rate for coronary lesions was higher (98.91% vs. 94.19%) in the 640 compared with the 64 group. In the 64 group, the incidence of artifacts in patients with a heart rate >65 bpm (20.98%) was higher than in those with a heart rate <65 bpm (15.67%), although the difference was not significant, while the incidence of artifacts was significantly higher in patients with heart arrhythmia (21.40%) compared with in those with normal heart rhythm (15.09%).
Conclusions:
Among patients with pacemakers and a higher heart rate or heart arrhythmia, 640-slice CT may be more effective than 64-slice CT for diagnosing coronary lesions, by reducing moderate and severe artifacts.
More Related Videos
Related Concept Videos
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography
Reducing Line Loss
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Adaptations that Reduce Water Loss
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...

