Autoimmunity in lichen planopilaris patients
Agata Kłosowicz1, Karolina Englert1, Karolina Pełka1
1Department of Dermatology, Jagiellonian University, Collegium Medicum, Cracow, Poland.
Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|February 28, 2019
Summary
High rates of antinuclear antibodies (ANA) were found in Lichen planopilaris (LPP) patients. Specific antibodies like anti-dsDNA and anti-Ro/anti-SSA were identified, suggesting a potential link between these autoimmune markers and LPP.
Area of Science:
- Dermatology
- Immunology
- Rheumatology
Background:
- Lichen planopilaris (LPP) is a rare, scarring alopecia causing irreversible hair loss due to hair follicle stem cell destruction.
- Antinuclear antibodies (ANA) are established biomarkers for various rheumatological conditions.
Purpose of the Study:
- To investigate the frequency of ANA positivity in patients diagnosed with Lichen planopilaris.
- To identify specific autoantibodies present in LPP patients.
Main Methods:
- The study included 57 patients (96% female, aged 28-79) with LPP treated at a University Hospital.
- ANA detection was performed using indirect immunofluorescence on HEp-2 cells and immunoblot testing.
Main Results:
- ANA were detected in 84.2% (48 out of 57) of LPP patients.
- Specific antibody profiles were identified in 46% (22 out of 57) of patients, with anti-dsDNA and anti-Ro/anti-SSA being the most prevalent.
Conclusions:
- A high prevalence of ANA was observed in the studied LPP patient cohort.
- The presence of specific autoantibodies like anti-dsDNA and anti-Ro/anti-SSA in LPP warrants further investigation into potential autoimmunepathogenesis.
Keywords:
antinuclear antibodiesautoimmunitycicatrical alopeciafrontal fibrosing alopecialichen planopilarisprimaryMore Related Videos
Related Concept Videos
01:29Autoimmune Disorders
1.7K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.7K
01:13Patient-centered Care
3.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
01:15Drug Dosing: Geriatric Patients
232
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
232
01:21Drug Dosing: Obese Patients
254
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
254
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
202
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
202
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
225
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
225