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Published on: October 12, 2017
Low serum apolipoprotein A-I in acute myocardial infarction survivors with normal HDL cholesterol
Insights
Younger men surviving acute myocardial infarction (AMI) showed reduced plasma apolipoprotein A-I (apo A-I) levels. Other cardiovascular risk factors like HDL cholesterol and sex hormones remained unchanged compared to controls.
Area of Science:
- Cardiology
- Biochemistry
- Endocrinology
Background:
- Acute myocardial infarction (AMI) survivors often have altered lipid profiles and hormonal balances.
- Understanding these changes is crucial for secondary prevention in younger patients.
Purpose of the Study:
- To investigate plasma levels of key cardiovascular biomarkers in non-diabetic males who experienced AMI before age 60.
- To compare these biomarkers between AMI survivors with different diastolic blood pressure levels and a healthy reference group.
Main Methods:
- Plasma samples from AMI survivors (n=60) and age-matched controls (n=32) were analyzed.
- Measurements included high-density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apo A-I), gamma-glutamyl-transferase, testosterone, and oestradiol.
- AMI patients were subgrouped based on diastolic blood pressure (<90 mm Hg vs. ≥95 mm Hg).
Main Results:
- No significant differences were observed in HDL cholesterol, gamma-glutamyl-transferase, testosterone, or oestradiol levels between AMI groups and controls.
- Significantly reduced plasma levels of apolipoprotein A-I (apo A-I) were detected in both AMI survivor groups compared to the reference group.
Conclusions:
- Reduced apo A-I may be a specific biomarker in younger male AMI survivors, independent of other common risk factors.
- Further research is warranted to explore the clinical implications of low apo A-I in this population.
Abstract:
High density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apo A-I), gamma-glutamyl-transferase, testosterone and oestradiol were determined in plasma in non-diabetic males who had survived an acute myocardial infarction (AMI) before the age of 60. They also had serum levels of cholesterol below 7.0 mmol/l 1 year after the AMI. On the basis of diastolic blood pressure they were subdivided into 2 groups with diastolic blood pressures below 90 mm Hg (n = 39), and with or above 95 mm Hg (n = 21) and then compared with an age-matched male non-diabetic reference group (n = 32). There were no significant differences in the levels of HDL cholesterol, gamma-glutamyl-transferase, and sex hormones between the AMI groups and the reference group. Reduced plasma levels of apo A-I were found in the AMI groups.
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