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Published on: August 21, 2021
Autologous nanofat transplantation accelerates foot wound healing in diabetic rats
Li Chen1, Zheng-Cai Wang1, Jing-Jing Ma1
1Department of Plastic & Reconstructive Surgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hang Zhou 310016, PR China.
Abstract:
Aim: This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Materials & methods: Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation. Results: Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression. Conclusion: This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.
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