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Optical biometry-based axial length alterations after intravitreal dexamethasone implant
Sadık Altan Ozal1, Ayca Kupelı1, Ece Ozal2
1Trakya University School of Medicine, Department of Ophthalmology, Edirne, Turkey.
Arquivos Brasileiros De Oftalmologia
|February 28, 2019
Summary
Intravitreal dexamethasone implantation reduced macular edema and increased axial length in patients. This finding highlights the impact of steroid treatment on ocular biometry, important for managing retinal conditions.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Macular edema is a significant cause of vision loss.
- Diabetic retinopathy, retinal vein occlusion, and uveitis are common causes of macular edema.
- Intravitreal corticosteroids are used to treat various forms of macular edema.
Purpose of the Study:
- To investigate changes in axial length following intravitreal dexamethasone implantation.
- To assess the effect of dexamethasone on central macular thickness.
- To compare outcomes in treated eyes versus control fellow eyes.
Main Methods:
- Prospective comparative study of 46 patients with unilateral macular edema.
- Dexamethasone implantation in the study group; fellow eyes served as controls.
- Central macular thickness measured by spectral-domain optical coherence tomography; axial length by IOLMaster 700.
Main Results:
- Central macular thickness significantly decreased in the study group (460.19 to 324.00 mm) post-implantation (p=0.000).
- Axial length significantly increased in the study group (23.16 to 23.22 mm) post-implantation (p=0.039).
- No significant changes in central macular thickness or axial length were observed in the control group.
Conclusions:
- Intravitreal dexamethasone implantation effectively reduces central macular thickness.
- Dexamethasone implantation also causes a significant change in optical biometry-based axial length measurements.
- These findings are crucial for understanding the ocular effects of dexamethasone treatment.
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