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Updated: Jan 28, 2026
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Power Input Measurements in Stirred Bioreactors at Laboratory Scale
Published on: May 16, 2018
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Recent developments in bioreactor scale production of bacterial polyhydroxyalkanoates
Zulfiqar Ali Raza1, Muhammad Rizwan Tariq2,3, Muhammad Irfan Majeed3
1Department of Applied Sciences, National Textile University, Faisalabad, 37610, Pakistan. zarazapk@yahoo.com.
Bioprocess and Biosystems Engineering
|February 28, 2019
Summary
Polyhydroxyalkanoates (PHAs) are biodegradable bioplastics produced by microorganisms. This review explores recent advancements in sustainable, large-scale PHA bioreactor production and future research directions.
Area of Science:
- Biotechnology
- Polymer Science
- Microbiology
Background:
- Polyhydroxyalkanoates (PHAs) are microbial biopolyesters serving as sustainable alternatives to conventional plastics.
- Microorganisms synthesize and store PHAs as intracellular energy reserves.
- PHAs are produced via microbial fermentation under controlled conditions.
Purpose of the Study:
- To review recent developments in the bioreactor-scale production of PHAs.
- To identify key factors influencing PHA production in bioreactors.
- To highlight future research avenues for sustainable PHA manufacturing.
Main Methods:
- Literature review of recent scientific publications on PHA production.
- Analysis of factors affecting PHA yield and productivity in bioreactors.
- Discussion of various microbial PHA production strategies.
Main Results:
- Bioreactor scale-up of PHA production is influenced by carbon source, nutrient availability, temperature, pH, and dissolved oxygen.
- Diverse microorganisms are capable of producing PHAs, offering a sustainable bioplastic source.
- PHAs have significant applications, especially in the medical field.
Conclusions:
- Sustainable bioreactor production of PHAs is achievable through optimization of fermentation parameters.
- Further research is needed to enhance efficiency and broaden the applications of PHAs.
- PHAs represent a promising class of bioplastics with considerable environmental and industrial potential.
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