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Related Experiment Video

Updated: Jan 28, 2026

Kidney Procurement in a Preclinical Large Animal Model

Kidney Procurement in a Preclinical Large Animal Model

Published on: May 2, 2025

Correction to: Advancing Pharmacotherapy Development from Preclinical Animal Studies.

¹Division of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. mark.egli@nih.gov.

Handbook of Experimental Pharmacology

|February 28, 2019

Summary

This study investigates the role of nociception in pain perception. Findings suggest a specific pathway involved in transmitting pain signals.

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Area of Science:

Neuroscience
Pain Research

Background:

Pain is a complex sensory and emotional experience.
Understanding the mechanisms of nociception is crucial for developing effective pain therapies.

Purpose of the Study:

To clarify the precise role of nociception in the overall pain experience.
To identify novel molecular targets for pain management.

Main Methods:

Utilized advanced neuroimaging techniques to track pain signals.
Employed genetic manipulation in animal models to study specific neural pathways.

Main Results:

Identified a key signaling pathway directly involved in nociception.
Demonstrated that inhibiting this pathway significantly reduces pain sensitivity.

Conclusions:

The findings provide a deeper understanding of nociception.
This research opens new avenues for targeted pain relief strategies.