Related Experiment Video
Updated: Jan 28, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Biological and chemical changes in fluoroquinolone-associated tendinopathies: a systematic review
Domenico Rocco Bisaccia1, Rocco Aicale2, Domiziano Tarantino2
1Department of Pharmacology, School of Medicine and Surgery, University of Salerno, Salerno, Italy.
Introduction:
The present systematic review investigates the biological and chemical mechanisms that affect the health and structure of tendons following the use of fluoroquinolones (FQs).
Sources Of Data:
A total of 12 articles were included, organized, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Areas Of Agreement:
Five mechanisms were identified: arrest of proliferation through a decreased activity of cyclin B, CDK-1, CHK-1, and increased PK-1; decrease tenocytes migration through decreased phosphorylation of FAK; decrease type I collagen metabolism through increased MMP-2; chelate effect on ions that influence epigenetics and several enzymes; fluoroquinolones-induced ROS (radical oxygen species) production in mitochondria.
Areas Of Controversy:
There is no definite structure-damage relationship. The dose-effect relationship is unclear.
Growing Points:
Knowing and defining the damage exerted by FQs plays a role in clinical practice, replacing FQs with other antibacterial drugs or using antioxidants to attenuate their pathological effects.
Areas Timely For Developing Research:
Clinical and basic sciences studies for each FQs are necessary.
More Related Videos
Related Concept Videos
Chemical Equilibria: Systematic Approach to Equilibrium Calculations
The first step is to identify all the chemical reactions involved, The...
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Random and Systematic Errors
Systematic Sampling Method
Systematic sampling is one of the simplest methods...
What is Conservation Biology?

