Electrically conductive nanofibrous scaffold composed of poly(ethylene glycol)-modified polypyrrole and
Bakhshali Massoumi1, Maryam Hatamzadeh1, Nima Firouzi2
1Department of Chemistry, Payame Noor University, P.O. Box: 19395-3697, Tehran, Iran.
Abstract:
The aim of this study was to developing two novel nanofibrous scaffolds composed of poly(ethylene glycol)-modified polypyrrole [PEG-b-(PPy)4] and poly(ε-caprolactone) (PCL) for tissue engineering (TE) applications. For this purpose, pyrrole-functionalized PEGs AB4 macromonomers (PyPEGsM) were synthesized through the Steglich esterification of PEGs ends-caped tetraol [PEGs(OH)4] using pyrrole-2-carboxylic acid. These macromonomers were subsequently copolymerized with pyrrole monomer using chemical oxidation polymerization approach to produce PEGs-b-(PPy)4 copolymers. A solution of PCL and the synthesized PEGs-b-(PPy)4 copolymers were electrospun to fabricate uniform, conductive, and biocompatible nanofibrous scaffolds. The performances of the fabricated nanofibers as TE scaffolds were examined in terms of biological (biocompatibility and biodegradability) as well as physicochemical (electroactivity, conductivity, mechanical properties, and morphology) features. As the results, the fabricated electrospun nanofibers were found as proper scaffolds for use in TE applications that require electroactivity.
More Related Videos
10:18Fabrication of Inverted Colloidal Crystal Polyethylene glycol Scaffold: A Three-dimensional Cell Culture Platform for Liver Tissue Engineering
Published on: August 27, 2016
10:50Optimizing Attachment of Human Mesenchymal Stem Cells on Poly(ε-caprolactone) Electrospun Yarns
Published on: April 10, 2015
Related Concept Videos
Electrical Conductivity
In a practical conductor, an applied electric field may be sustained, causing a flow of electrons, which produce a current. The differential form of the current, the current density, is related to the electric field.
More generally, it is related to the force per unit charge, which involves the...
Electric Field of Parallel Conducting Plates
Consider a cross-section of a thin, infinite conducting plate having a positive charge. For such a large thin plate, as the thickness of the plate tends to zero, the positive charges lie on the plate's two large faces. Without an external electric field, the...
Induced Electric Fields: Applications
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Conduction System of the Heart
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Conduction System of the Heart
This system relies on the unique properties of nodal and Purkinje cells:...
