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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Imatinib-induced irreversible interstitial lung disease: A case report
Ping Zhang1, Jingfeng Huang2, Fangfang Jin1
1Department of Hematology.
Medicine
|March 1, 2019
Summary
Imatinib treatment for chronic myeloid leukemia can rarely cause irreversible interstitial lung disease (ILD). Careful monitoring is crucial for patients receiving imatinib to detect and manage this severe adverse effect.
Area of Science:
- Oncology
- Pulmonology
- Pharmacology
Background:
- Imatinib mesylate is a tyrosine kinase inhibitor for chronic myeloid leukemia.
- Rare cases of imatinib-associated pulmonary interstitial fibrosis (a form of interstitial lung disease) have been reported.
- Clinical features of imatinib-induced interstitial lung disease (ILD) are not well understood due to its rarity.
Observation:
- A 49-year-old man with chronic myeloid leukemia developed cough and fever 9 months after starting imatinib.
- Pulmonary CT revealed diffuse interstitial fibrosis.
- Infections were ruled out, and initial antibiotic treatment was ineffective.
Findings:
- Imatinib was discontinued, and prednisone was initiated, leading to symptom improvement.
- Reintroduction of imatinib caused recurrence of cough and dyspnea.
- Switching to nilotinib resulted in symptom amelioration, but CT scans showed irreversible pulmonary interstitial fibrosis 29 months post-diagnosis.
Implications:
- Clinicians must consider imatinib-induced ILD in patients with respiratory symptoms.
- Careful monitoring for ILD is essential during imatinib therapy.
- Pulmonary interstitial fibrosis associated with imatinib can be severe and irreversible.
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