Yinchenhao decoction for chronic hepatitis B: Protocol for a systematic review and meta-analysis

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Lu Xu1, Tian Xie2, Tao Shen1

  • 1School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan.

Medicine
|March 1, 2019
PubMed

Insights

This systematic review evaluates Yinchenhao decoction (YCHD) for chronic hepatitis B (CHB). It synthesizes evidence on YCHD

Area of Science:

  • Hepatology and Gastroenterology
  • Integrative and Complementary Medicine
  • Pharmacological Sciences

Background:

  • Chronic hepatitis B (CHB) poses a significant global health risk, leading to cirrhosis and hepatocellular carcinoma (HCC).
  • Yinchenhao decoction (YCHD), a traditional Chinese medicine, is recognized for treating jaundice.
  • The clinical efficacy of YCHD for CHB is promising, but its safety profile requires thorough investigation.

Purpose of the Study:

  • To systematically review and assess the clinical efficacy and safety of Yinchenhao decoction (YCHD) in treating patients with chronic hepatitis B (CHB).
  • To consolidate existing evidence regarding YCHD's impact on key virological and biochemical markers in CHB patients.

Main Methods:

  • A comprehensive literature search was conducted across major Chinese and English electronic databases up to January 2019.
  • Included studies focused on YCHD therapy for CHB, with primary outcomes being HBV-DNA levels, HBeAg status, and ALT levels.
  • Data synthesis for meta-analysis will be performed using RevMan V.5.3 software where appropriate.

Main Results:

  • The review will compile evidence on YCHD's effects on HBV-DNA, HBeAg, and ALT levels in CHB patients.
  • It will also evaluate TCM syndrome criteria, quality of life changes, and reported adverse events associated with YCHD treatment.
  • A high-quality composite of evidence will be presented to inform clinical practice.

Conclusions:

  • This systematic review aims to provide robust evidence regarding the clinical effectiveness of YCHD for treating chronic hepatitis B.
  • The findings will help clarify the role of YCHD in CHB management and inform future research on its safety and efficacy.
Abstract

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