Gender Differences with Dose⁻Response Relationship between Serum Selenium Levels and Metabolic Syndrome-A...

Area of Science:

• Biochemistry
• Human Physiology
• Nutritional Science

Background:

• Metabolic syndrome is a growing public health concern.
• Limited research exists on the relationship between selenium and metabolic syndrome.
• Understanding nutrient associations is crucial for preventative health strategies.

Purpose of the Study:

• To investigate the association between serum selenium levels and metabolic syndrome.
• To examine the relationship between serum selenium and individual metabolic factors.
• To explore potential sex-specific differences in these associations.

Main Methods:

• Case-control study involving 1165 adults aged 40 years and older.
• Serum selenium levels measured using inductively coupled plasma-mass spectrometry.
• Statistical analyses included multivariate logistic regression and general linear models.

Main Results:

• Mean serum selenium was 96.34 ± 25.90 μg/L.
• Positive correlations observed between serum selenium and waist circumference, systolic blood pressure, triglycerides, fasting glucose, and HOMA-IR in women.
• Positive correlations found between serum selenium and fasting glucose and HOMA-IR in men.
• Increased odds of metabolic syndrome were associated with higher selenium quartiles, especially in women (p < 0.05).
• Non-linear dose-response trend identified between serum selenium and metabolic syndrome.
• Selenium positively associated with insulin resistance in both sexes, and with adiposity and lipid metabolism in women.

Conclusions:

• Serum selenium levels show a positive association with metabolic syndrome, particularly in women.
• Selenium concentration is linked to insulin resistance in both men and women.
• Associations with adiposity and lipid metabolism were observed in women, suggesting sex-specific effects.
• Further research is needed to elucidate the underlying mechanisms of these associations.