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Updated: Jan 28, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Targeting ALK in Cancer: Therapeutic Potential of Proapoptotic Peptides

Arthur Aubry1,2, Stéphane Galiacy3,4,5, Michèle Allouche6,7

  • 1Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada. arthur-aubry@hotmail.fr.

Cancers
|March 1, 2019
PubMed

Insights

Anaplastic lymphoma kinase (ALK) is a key target in cancer therapy. New strategies, including ALK-derived peptides, are needed to overcome resistance to current ALK inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase implicated in various cancers.
  • ALK-driven tumors rely on activated ALK for proliferation, making it a therapeutic target.
  • Current ALK inhibitors show efficacy but are limited by acquired tumor resistance.

Purpose of the Study:

  • To review the therapeutic potential of proapoptotic ALK-derived peptides.
  • To explore alternative treatment strategies for ALK-dependent and independent signaling pathways.
  • To address the need for novel therapies against ALK-driven tumors that develop resistance.

Main Methods:

  • Literature review focusing on ALK as a cancer target.
  • Analysis of ALK's dependence receptor properties for therapeutic peptide development.
  • Compilation of alternative treatments targeting ALK signaling pathways.

Main Results:

  • ALK is a validated target across diverse tumor types.
  • Tyrosine kinase inhibitors targeting ALK are approved but face resistance.
  • Proapoptotic ALK-derived peptides represent a promising therapeutic avenue.
  • Alternative and combination therapies are crucial for sustained tumor control.

Conclusions:

  • Targeting ALK remains critical in oncology.
  • Overcoming resistance to ALK inhibitors requires novel therapeutic approaches.
  • ALK-derived peptides and combination strategies offer potential for improved cancer treatment outcomes.
Keywords:
ALKanaplastic large cell lymphomaanaplastic lymphoma kinasedependence receptorneuroblastomanon-small-cell lung cancerproapoptotic peptidestargeted therapytyrosine kinasetyrosine kinase inhibitor

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