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Neuronanomedicine: An Up-to-Date Overview
Daniel Mihai Teleanu1, Cristina Chircov2,3, Alexandru Mihai Grumezescu4,5
1Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. daniel.teleanu@umfcd.ro.
Pharmaceutics
|March 1, 2019
Summary
Neuronanomedicine uses nanotechnology for diagnosing and treating central nervous system disorders. Nanocarriers crossing the blood-brain barrier (BBB) offer promising new therapies for brain diseases.
Area of Science:
- Neuronanomedicine
- Nanotechnology
- Neurological Sciences
Background:
- The emergence of neuronanomedicine integrates nanotechnology with neurological sciences.
- This interdisciplinary field holds significant promise for diagnosing and treating central nervous system (CNS) disorders.
- Developing nano-vehicles that can penetrate the blood-brain barrier (BBB) is crucial for effective brain-targeted therapies.
Purpose of the Study:
- To review recent advancements in nanocarrier development for brain drug delivery.
- To summarize the application of nanocarriers in treating brain cancer, neurodegenerative diseases, and stroke.
- To highlight the challenges and limitations of using nanocarriers for CNS disorders.
Main Methods:
- Review of recent literature on organic, inorganic, and biological nanocarriers.
- Analysis of studies utilizing nanocarriers for imaging and therapeutic agent delivery to the brain.
- Examination of research on nanomaterial applications in specific neurological conditions.
Main Results:
- Various nanocarriers (organic, inorganic, biological) show potential for BBB penetration.
- Nanomaterials are being investigated for targeted delivery in brain cancer, neurodegenerative diseases, and stroke.
- Significant progress has been made in developing nanomedicines for neurological applications.
Conclusions:
- Nanotechnology offers innovative strategies for treating severe brain disorders.
- Overcoming the BBB remains a key challenge in nanomedicine for CNS diseases.
- Further research is needed to address limitations and optimize nanocarrier efficacy and safety.
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