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Paternal contributions to large-for-gestational-age term babies: findings from a multicenter prospective cohort study

J G B Derraik1,2,3, D Pasupathy4, L M E McCowan5,6

  • 1Liggins Institute, University of Auckland, Auckland, New Zealand.

Journal of Developmental Origins of Health and Disease
|March 1, 2019
PubMed

Insights

Paternal birth weight and height are linked to a higher risk of infants being born large-for-gestational-age (LGA). However, maternal body mass index (BMI) plays a more significant role in determining LGA risk.

Area of Science:

  • Reproductive Health
  • Pediatrics
  • Genetics

Background:

  • Large-for-gestational-age (LGA) infants are associated with increased risks of adverse neonatal outcomes and long-term health issues.
  • Understanding factors contributing to LGA is crucial for developing targeted interventions.
  • While maternal factors are well-studied, paternal influences on fetal growth require further investigation.

Purpose of the Study:

  • To investigate the association between paternal demographic, anthropometric, and clinical factors and the likelihood of an infant being born large-for-gestational-age (LGA).

Main Methods:

  • Analysis of data from 3659 fathers of term infants from the Screening for Pregnancy Endpoints (SCOPE) cohort.
  • LGA defined as birth weight >90th centile using INTERGROWTH 21st standards.
  • Univariable and multivariable regression models were used to examine associations between paternal factors and LGA.

Main Results:

  • Fathers of LGA infants were significantly heavier at birth and more likely to have been born macrosomic.
  • Paternal height and paternal weight at birth were independently associated with increased odds of having an LGA infant.
  • Paternal BMI showed a transient association with LGA in boys, which diminished after adjusting for maternal BMI; maternal BMI had a dominant influence.

Conclusions:

  • Paternal factors, specifically higher birth weight and greater height, are associated with an increased risk of having a large-for-gestational-age infant.
  • Maternal BMI is a more dominant factor influencing the risk of LGA compared to paternal factors.
  • Further research may explore the interplay between parental anthropometrics and fetal growth.

Keywords:
BMI, body mass indexLGAbirth weightfathermother

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