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Related Experiment Video

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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

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Published on: October 31, 2016

Shear-thickening fluids in biologically relevant agents.

Peter Kilbride¹, Marina Vazquez Rull¹, Adam Townsend²

¹Asymptote Ltd., General Electric Healthcare, Cambridge, UK.

|March 1, 2019

Summary

This study shows that shear thickening fluids made with hydroxyethyl starch and cryoprotectants can protect biological materials. These fluids work best at lower temperatures, offering potential for improved cryopreservation.

Keywords:

Cryopreservation colloids shear-thickening starch temperature-dependence

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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

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Published on: May 26, 2023

Area of Science:

Rheology
Biomaterials Science
Cryobiology

Background:

Shear thickening fluids (STFs) are well-understood in physical applications.
Limited research exists on STFs compatible with biological and cryobiological systems.

Purpose of the Study:

To investigate the shear-rate viscosity relationship of hydroxyethyl starch-based fluids with cryoprotectants.
To determine if these cryobiologically relevant materials can provide protection to biologics via shear-thickening.

Main Methods:

Examined fluids composed of 50% corn-derived hydroxyethyl starch by weight with various sugars and cryoprotectants.
Characterized the shear-rate viscosity relationship at different temperatures.
Compared shear-thickening properties of corn, wheat, and rice-derived starches.

Main Results:

50% hydroxyethyl starch fluids demonstrated shear thickening with various cryoprotectants.
Lowering temperature reduced critical shear rates and increased thickening magnitude.
Different starch sources (corn, rice, wheat) exhibited varied non-Newtonian behavior, with corn and rice starches forming STFs.

Conclusions:

Shear thickening is compatible with cryobiologically relevant agents, especially at reduced temperatures.
This compatibility provides a foundation for utilizing shear-thickening phenomena in biological applications like cryopreservation.