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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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Signal Transduction: Overview01:26

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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¹H NMR Signal Integration: Overview00:58

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The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...
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Endocrine Signaling01:45

Endocrine Signaling

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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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Related Experiment Video

Updated: Jan 28, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
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[The bone and Wnt signaling : overview.]

Mikihito Hayashi1, Tomoki Nakashima1

  • 1Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University/Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology（AMED-CREST）, Tokyo, Japan.

Clinical Calcium
|March 1, 2019
PubMed
Summary

Targeting the Wnt signaling pathway with a sclerostin antibody may enhance bone mass. This approach could offer a new treatment strategy to reduce fracture risk in patients with bone disorders.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Endocrinology

Background:

  • The Wnt signaling pathway regulates critical biological processes like embryonic development and tissue homeostasis.
  • Mutations in low density lipoprotein receptor-related protein 5 (LRP5) are linked to human bone disorders, highlighting Wnt signaling's role in bone.
  • Wnt signaling is a key regulator of bone metabolism.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting the Wnt signaling pathway for bone health.
  • To explore the efficacy of a monoclonal antibody against sclerostin for improving bone mass and reducing fracture risk.

Main Methods:

  • Utilized a monoclonal antibody targeting sclerostin, a Wnt inhibitor.
  • Focused on the Wnt signaling pathway's role in bone cells and metabolism.

Main Results:

  • Sclerostin antibody treatment has the potential to improve bone mass.
  • This therapeutic strategy may decrease the risk of fractures.

Conclusions:

  • Modulating Wnt signaling by inhibiting sclerostin is a promising therapeutic avenue for bone disorders.
  • Targeting sclerostin offers a potential treatment to enhance bone density and mitigate fracture risk.