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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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Updated: Jan 28, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

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[Canonical Wnt signaling pathway and current issues.]

Katsumi Fumoto1, Akira Kikuchi1

  • 1Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Clinical Calcium
|March 1, 2019
PubMed
Summary

The Wnt signaling pathway, crucial for development and disease, has revealed new mechanisms. Recent studies analyzed Wnt-receptor complexes, cell surface regulation, and intracellular protein interactions for deeper understanding.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Developmental Biology

Background:

  • Wnt signaling pathways regulate gene expression and cellular processes.
  • The canonical Wnt pathway, dependent on β-catenin, is vital in development, tumorigenesis, and regeneration.
  • Understanding Wnt signaling is critical for various biological research areas.

Purpose of the Study:

  • To elucidate novel mechanistic insights into the canonical Wnt signaling pathway.
  • To explore the structural and regulatory aspects of Wnt signaling.
  • To provide a comprehensive overview of recent advancements in canonical Wnt pathway research.

Main Methods:

  • Analysis of Wnt-receptor complex structures.
  • Investigation of Wnt signaling regulation at the cell surface membrane.

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  • Examination of intracellular protein complexes involved in Wnt signaling.

    • Main Results:

    • New mechanistic insights into the canonical Wnt signaling pathway have been clarified.
    • Structural analysis of the Wnt-receptor complex provided key details.
    • Regulation of Wnt signaling at the cell surface and intracellularly was further understood.

    Conclusions:

    • Recent research has significantly advanced the understanding of canonical Wnt signaling mechanisms.
    • The study highlights the importance of Wnt-receptor interactions and cellular regulation.
    • Further research into Wnt signaling holds promise for therapeutic applications in development and disease.