Related Experiment Video
Updated: Jan 28, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
[Regulations of osteoclast formation and function by Wnt signals.]
Yasuhiro Kobayashi1, Shunsuke Uehara1, Masanori Koide2
1Institute for Oral Science Hard tissue research, Matsumoto Dental University, Shiojiri, Nagano, Japan.
Abstract:
Wnt ligands activate β-catenin-dependent canonical and -independent non-canonical signaling pathways. Recent studies established importance of Wnt/β-catenin signaling in bone accrual. Antibodies against the Wnt inhibitor sclerostin and those against the Wnt inhibitor Dickkopf-1 have been shown to be effective for increasing bone mass. In addition to their effects on bone formation, roles of Wnt signals in bone resorption are gradually clarified. In this review, we would like to introduce recent advances in roles of Wnt signals in osteoclast formation and functions and regulation of sclerostin expression by osteoclasts.
Related Concept Videos
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Testosterone: Functions and Regulation
GTPases and their Regulation
Large G-proteins,...
Osteoclasts in Bone Remodeling
Functional Brain Systems: Reticular Formation
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

