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Updated: Jan 28, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
[Wnt signaling in myeloma.]
1Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan.
Abstract:
Multiple myeloma(MM)develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. A variety of cytokines are overproduced in MM to stimulate RANKL-mediated osteoclastogenesis while suppressing osteoblastic differentiation from bone marrow stromal cells, leading to extensive bone destruction with rapid loss of bone. Soluble Wnt inhibitors elaborated from MM cells and/or their surrounding cells in bone lesions play an important role. Novel therapeutic neutralizing antibodies against DKK-1 or sclerotin are expected as bone anabolic agents;however, their effects on MM tumor progression through activation of the Wnt/β-catenin pathway remain to be carefully clarified.
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