Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys

Area of Science:

• Veterinary Medicine
• Parasitology
• Primate Health

Background:

• Balantidium coli infections pose a challenge in captive primate populations due to limited effective treatments.
• Effective antimicrobial strategies are crucial for maintaining the health and well-being of cynomolgus monkeys.

Purpose of the Study:

• To evaluate the efficacy and safety of paromomycin sulfate (PS) for treating Balantidium coli infections in captive cynomolgus monkeys.
• To establish an optimal dosage and administration protocol for PS in this species.

Main Methods:

• A study involving 596 captive cynomolgus monkeys was conducted.
• Paromomycin sulfate was administered orally at a minimum dose of 25 mg/day for 5 + 5 days with a 2-day withdrawal interval.
• Pumpkin cakes supplemented with PS were utilized to ensure precise dosing and efficient administration.

Main Results:

• No Balantidium coli cysts or trophozoites were detected 14 or 16 days post-treatment.
• No significant alterations in blood or biochemical parameters were observed before and after PS administration.
• The use of PS-supplemented pumpkin cakes improved preparation and administration efficiency.

Conclusions:

• Paromomycin sulfate is an effective and safe antimicrobial agent for eliminating Balantidium coli in cynomolgus monkeys.
• PS treatment did not result in hematological side effects, indicating a favorable safety profile.
• These findings support the use of PS for controlling Balantidium coli in primate colony management and veterinary care.