Related Experiment Video

Updated: Jan 28, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.4K

Differential Effectiveness of Landiolol Between Atrial Fibrillation and Atrial Flutter/Atrial Tachycardia Patients

Eiichiro Oka1, Yu-Ki Iwasaki1, Eugene Maru1

  • 1Department of Cardiovascular Medicine, Nippon Medical School.

Circulation Journal : Official Journal of the Japanese Circulation Society
|March 1, 2019
PubMed

Insights

Landiolol effectively controlled heart rate in patients with atrial fibrillation (AF) but was largely ineffective for atrial flutter/tachycardia (AFl/AT) in those with reduced left ventricular function.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Landiolol is an ultra-short acting beta-1 selective blocker used for heart rate control.
  • Its effectiveness in different atrial tachyarrhythmias with left ventricular dysfunction is not fully understood.

Purpose of the Study:

  • To evaluate landiolol's efficacy and safety in patients with reduced left ventricular function presenting with tachycardiac atrial fibrillation (AF) versus tachycardiac atrial flutter/atrial tachycardia (AFl/AT).

Main Methods:

  • Retrospective analysis of 77 patients treated with landiolol.
  • Comparison of heart rate changes and treatment response between AF and AFl/AT groups.
  • Assessment of the need for alternative treatments.

Main Results:

  • Landiolol demonstrated significantly greater heart rate reduction in the AF group compared to the AFl/AT group.
  • A higher proportion of patients with AF responded to landiolol treatment than those with AFl/AT.
  • 83% of AFl/AT patients required alternative treatments like amiodarone or cardioversion.

Conclusions:

  • Landiolol is largely ineffective for managing tachycardiac atrial flutter/atrial tachycardia in patients with reduced left ventricular function.
  • Alternative management strategies should be considered for these patients to prevent heart failure exacerbation.
Abstract

Keywords:
Atrial fibrillationAtrial flutter/atrial tachycardiaHeart failureLandiololLeft ventricular dysfunction

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.9K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.1K

Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
533
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.9K
Amyloid Fibrils03:03

Amyloid Fibrils

6.4K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
202
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Buffer Effectiveness02:19

Buffer Effectiveness

Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.1K