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Updated: Jan 28, 2026
09:51
One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
11.2K
Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy.
Arjun Prasad Tiwari1,2, Deval Prasad Bhattarai3,4, Bikendra Maharjan3
1Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, 561-756, Republic of Korea.
Scientific Reports
|March 1, 2019
Summary
This study developed a novel platform using polydopamine-coated fibers for localized cancer therapy. The material demonstrated dual pH and near-infrared light responsiveness, enhancing drug release and improving cancer cell death.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Therapy
Background:
- Developing localized and stimuli-responsive drug delivery systems is crucial for effective cancer treatment.
- Polydopamine (PDA) offers versatile properties for surface modification and stimuli-responsive applications.
- Electrospun fibers provide a scaffold for controlled drug release and localized therapy.
Purpose of the Study:
- To design and fabricate a multifunctional localized platform for cancer therapy using stimuli-responsive polydopamine (PDA).
- To investigate the photothermal properties and stability of PDA-modified electrospun fibers.
- To evaluate the pH and near-infrared (NIR) dual-responsive drug release and in vitro anticancer efficacy.
Main Methods:
- Surface modification of doxorubicin hydrochloride (DOX) loaded polycaprolactone (PCL) fibers with PDA.
- Characterization of photothermal performance under 808 nm NIR laser irradiation.
- In vitro drug release studies at different pH conditions and in response to NIR exposure.
- Evaluation of anticancer activity using cell counting (CCK) and live/dead cell assays.
Main Results:
- PDA incorporation significantly enhanced photothermal performance and stability under NIR irradiation in a concentration-dependent manner.
- PDA-coated PCL-DOX fibers exhibited pH and NIR dual-responsive drug release, with enhanced release in acidic conditions and upon NIR exposure.
- Combined chemo-photothermal therapy demonstrated improved cancer cell death compared to individual treatments.
Conclusions:
- The developed PDA-coated PCL-DOX fibrous platform shows promising dual stimuli-responsive behavior for localized cancer therapy.
- This multifunctional platform integrates photothermal properties with controlled drug release for enhanced therapeutic outcomes.
- The study presents a significant advancement towards a therapeutic model for cancer treatment leveraging PDA's unique properties.
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