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Updated: Jan 28, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Using conversational agents to explain medication instructions to older adults
Renato F L Azevedo1,2,3, Dan Morrow1, James Graumlich2
1UIUC, Urbana-Champaign, IL.
Computer agents (CAs) can improve medication information recall for older adults by eliciting social responses. Different CA designs and message framing impact patient learning and engagement.
Area of Science:
- Human-Computer Interaction
- Gerontology
- Health Informatics
Background:
- Developing effective computer agent (CA) based systems for patient-centered communication is crucial, especially for older adults receiving medication instructions.
- Understanding how CA design and message framing influence patient responses is essential for optimizing health information delivery.
Purpose of the Study:
- To evaluate older and younger adults' responses to medication information presented by computer agents (CAs) with varying appearances and message framing.
- To assess the impact of CA realism, expressiveness, and message framing (gains vs. losses) on patient memory, affect, and perception of teaching effectiveness.
Main Methods:
- 360 older and younger adults were exposed to medication information delivered by CAs differing in appearance (photorealistic, cartoon, emoji) and message framing (gain vs. loss).
- Evaluated outcomes included patient memory for medication information, affective responses, perceived CA teaching effectiveness, expressiveness, and similarity.
Main Results:
- Computer agents (CAs) significantly impacted older adults' learning of medication information.
- Social responses engendered by CAs played a key role in enhancing learning outcomes for older adults.
- CA appearance and message framing influenced patient perceptions and memory, suggesting design implications for health communication systems.
Conclusions:
- Computer agents (CAs) can be effective tools for delivering medication information to older adults, particularly by leveraging social interaction principles.
- Tailoring CA design and communication strategies to elicit positive social responses can enhance patient understanding and adherence to medication instructions.
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