Related Experiment Video

Updated: Jan 28, 2026

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
09:06

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

1.1K

In vitro interactions of crocin with fluconazole against Candida isolates

Narges Aslani1, Mohammad Taghi Hedayati2,3, Mojtaba Nabili4

  • 1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Current Medical Mycology
|March 1, 2019
PubMed
Abstract

Insights

Crocin showed high minimum inhibitory concentration (MIC) values against Candida species, indicating limited antifungal activity. Combining crocin with fluconazole did not significantly enhance its efficacy against these fungal infections.

Area of Science:

  • Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Rising incidence of invasive fungal infections.
  • Emergence of azole-resistant fungal species due to widespread azole drug use.
  • Urgent need for novel strategies to manage Candida infections.

Purpose of the Study:

  • Evaluate the antifungal activity of crocin (Cro) alone.
  • Assess the combined effect of crocin and fluconazole against Candida species.

Main Methods:

  • Utilized 50 clinical isolates of four Candida species.
  • Confirmed isolate identity using the internal transcribed spacer identification system.
  • Employed microdilution checkerboard method and fractional inhibitory concentration index (FICI) to determine drug interactions.

Main Results:

  • Crocin exhibited a high MIC50 value (1 µg/ml) against Candida species.
  • Interactions between crocin and fluconazole were largely indifferent, with FICI ranging from 0.5 to 4.
  • Fluconazole did not significantly reduce the MIC of crocin.

Conclusions:

  • Crocin demonstrates insufficient antifungal activity against Candida species at the tested concentrations.
  • The combination of crocin and fluconazole does not offer synergistic antifungal effects.
  • High concentrations of crocin may involve mechanisms independent of azole drug pathways.
Keywords:
CandidaCombinationCrocinFluconazole

More Related Videos

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

2.1K
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

1.9K

Related Concept Videos

Predator-Prey Interactions02:39

Predator-Prey Interactions

Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.4K
Van der Waals Interactions01:24

Van der Waals Interactions

Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
71.2K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
7.4K
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.3K