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Systemic growth hormone deficiency causes mechanical and thermal hypersensitivity during early postnatal development
Zachary K Ford1, Adam J Dourson1, Xiaohua Liu1
1Department of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, United States.
IBRO Reports
|March 1, 2019
Summary
Growth hormone deficiency (GHD) in early life causes hypersensitivity to pain and alters nerve gene expression. These findings suggest growth hormone (GH) is crucial for regulating pain responses during development.
Area of Science:
- Neuroscience
- Developmental Biology
- Pain Research
Background:
- Early life injury can alter pain sensitivity into adulthood.
- Growth hormone (GH) regulates pain behaviors during developmental inflammation.
- Peripheral injury reduces GH levels, correlating with hypersensitivity.
Purpose of the Study:
- To determine if GH deficiency (GHD) alone causes peripheral sensitization in uninjured animals.
- To investigate the impact of GHD on nociceptive processing during early development.
Main Methods:
- Systemic GHD was induced via knockout of the GH release hormone receptor (GHRHr).
- Behavioral and afferent hypersensitivity were assessed.
- Dorsal root ganglion (DRG) gene expression was analyzed at postnatal days 7, 14, and 21.
Main Results:
- Systemic GHD induced behavioral and afferent hypersensitivity during early postnatal development (P7, P14).
- GHD led to upregulation of nociceptive-related receptors and channels in DRGs at P7 and P14.
- Altered DRG gene expression persisted at P21, despite resolution of behavioral hypersensitivity.
Conclusions:
- GH is a critical modulator of neonatal hypersensitivity.
- GHD is sufficient to induce developmental hypersensitivity and alter DRG gene expression.
- GH therapy may be a potential strategy for pediatric pain management.
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