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Updated: Jan 28, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
Sample sizes based on three popular indices of risks
Hongyue Wang1, Bokai Wang1, Xin M Tu2
1Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Abstract:
Sample size justification is a very crucial part in the design of clinical trials. In this paper, the authors derive a new formula to calculate the sample size for a binary outcome given one of the three popular indices of risk difference. The sample size based on the absolute difference is the fundamental one, which can be easily used to derive sample size given the risk ratio or OR.
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