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Adiponectin is associated with cardio-metabolic traits in Mexican children

Juehua He1, Carolina Stryjecki1, Hudson Reddon1

  • 1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.

Scientific Reports
|March 1, 2019
PubMed

Insights

Adiponectin levels in Mexican children strongly correlate with cardio-metabolic health markers like BMI and insulin resistance. Genetic variations in key adiponectin genes were not linked to these traits in this population.

Area of Science:

  • Endocrinology and Metabolism
  • Human Genetics
  • Pediatric Health

Background:

  • Adiponectin, an adipocyte-derived hormone, plays a crucial role in linking obesity to cardio-metabolic disorders.
  • Genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 are known to influence adiponectin levels and cardio-metabolic health in various ethnic groups.
  • However, the relationship between these genetic variants, adiponectin levels, and cardio-metabolic traits in Mexican children remains unexplored.

Purpose of the Study:

  • To investigate the associations between serum adiponectin concentrations and cardio-metabolic traits in Mexican children.
  • To examine the relationship between specific genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 and serum adiponectin levels and cardio-metabolic traits in this population.

Main Methods:

  • A cohort of 1,457 Mexican children from Mexico City was recruited.
  • Six genetic variants near ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped.
  • Serum adiponectin levels, genetic variants, and cardio-metabolic traits were analyzed using linear and logistic regressions, adjusting for age, sex, and recruitment center.

Main Results:

  • Serum adiponectin concentration showed significant negative associations with body mass index, waist-to-hip ratio, LDL cholesterol, total cholesterol, triglycerides, fasting glucose, fasting insulin, and insulin resistance (HOMA-IR).
  • A strong inverse relationship was observed between adiponectin levels and the prevalence of dyslipidemia and overweight/obesity.
  • No significant associations were found between the studied genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 and either serum adiponectin concentration or cardio-metabolic traits after Bonferroni correction.

Conclusions:

  • Circulating adiponectin concentration is strongly associated with various cardio-metabolic traits in Mexican children.
  • The investigated genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 do not appear to significantly influence adiponectin levels or cardio-metabolic health in this specific pediatric cohort.

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