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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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Adiponectin: A Predictor for Breast Cancer Survival?
Hikmet Erhan Güven1, Lütfi Doğan2, Mehmet Ali Gülçelik1
1Department of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey.
European Journal of Breast Health
|March 1, 2019
Summary
Lower serum adiponectin levels correlate with aggressive breast cancer phenotypes. Preoperative adiponectin levels may predict survival and guide treatment decisions for breast cancer patients.
Area of Science:
- Oncology
- Endocrinology
- Biochemistry
Background:
- Lower serum adiponectin levels are linked to more aggressive breast cancer phenotypes.
- Adiponectin, a key adipokine, plays a role in metabolic regulation and inflammation.
- Understanding adiponectin's role in breast cancer progression is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the relationship between preoperative serum adiponectin levels and breast cancer-specific survival.
- To determine if adiponectin levels can serve as a predictive marker for breast cancer outcomes.
- To analyze the association between adiponectin levels and different stages of breast cancer.
Main Methods:
- A case-controlled study involving 83 patients with Stage I-III breast cancer.
- Preoperative serum adiponectin concentrations were measured using ELISA.
- Patients had no prior medications influencing insulin resistance.
Main Results:
- Mean adiponectin level was 15,300 ng/mL.
- Adiponectin levels were significantly lower in higher stages of breast cancer.
- Higher adiponectin levels (above mean) were associated with improved Disease-Free Survival (DFS) and Overall Survival (OS).
Conclusions:
- Preoperative adiponectin levels may predict survival rates in breast cancer patients.
- Adiponectin could serve as a marker for identifying patients needing more aggressive treatment.
- Further large-scale studies are warranted to establish adiponectin as a clinical marker for breast cancer.
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