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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

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CDC20 contributes to the development of human cutaneous squamous cell carcinoma through the Wnt/β‑catenin signaling

Zhaowei Chu1, Xinyue Zhang1, Qingyan Li1

  • 1Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

International Journal of Oncology
|March 1, 2019
PubMed

Insights

Cell division cycle 20 (CDC20) is upregulated in cutaneous squamous cell carcinoma (cSCC), driving tumor growth and migration. Targeting CDC20 may offer a new therapeutic strategy for cSCC.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cell division cycle 20 (CDC20) is a key cell cycle regulator.
  • CDC20 has an oncogenic role in various human cancers.
  • The role of CDC20 in cutaneous squamous cell carcinoma (cSCC) remains uninvestigated.

Purpose of the Study:

  • To investigate the role and mechanism of CDC20 in cSCC tumorigenesis.
  • To determine if CDC20 expression correlates with cSCC pathological differentiation.

Main Methods:

  • Quantitative analysis of CDC20 expression in cSCC tissues and cell lines.
  • Functional assays assessing the impact of CDC20 downregulation on cell proliferation, cell cycle, apoptosis, and migration.
  • Investigation of CDC20's effect on the Wnt/β‑catenin signaling pathway.
  • Assessment of all‑trans‑retinoic acid's effect on CDC20 expression in cSCC.

Main Results:

  • CDC20 expression is significantly increased in cSCC tissues and cell lines.
  • Elevated CDC20 expression correlates with pathological differentiation in cSCC.
  • CDC20 downregulation inhibits proliferation, induces cell cycle arrest, promotes apoptosis, and reduces migration via Wnt/β‑catenin pathway inhibition.
  • All‑trans‑retinoic acid treatment downregulates CDC20 expression in cSCC.

Conclusions:

  • CDC20 plays a critical role in human cSCC tumorigenesis.
  • CDC20 inhibition presents a potential therapeutic strategy for cSCC.
  • CDC20 may serve as a novel biomarker for cSCC prevention, diagnosis, and treatment.

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