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Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells
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MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1

Zhisheng Wang1, Jiayun Zhang2, Songlan Zhang3

  • 1Medical Department of Shandong Medical College, Shandong 250002, P.R. China.

Molecular Medicine Reports
|March 1, 2019
PubMed

Insights

Serum exosomal microRNA (miRNA) miR-30e shows potential as a novel biomarker for coronary atherosclerosis diagnosis. Higher miR-30e levels correlate with disease, offering a new diagnostic avenue.

Area of Science:

  • Cardiovascular Biology
  • Molecular Diagnostics
  • Exosome Biology

Background:

  • Atherosclerosis, a leading cause of coronary artery disease (CAD), involves lipid and fibrous arterial buildup.
  • Altered exosomal microRNA (miRNA) profiles are linked to various diseases, including CAD.

Purpose of the Study:

  • To investigate the potential of specific exosomal miRNAs in serum as diagnostic biomarkers for coronary atherosclerosis.
  • To identify novel miRNA signatures associated with the pathogenesis of coronary atherosclerosis.

Main Methods:

  • Detection of nine candidate miRNAs in plasma exosomes from 42 coronary atherosclerosis patients.
  • Bioinformatics analysis and immunoblotting to confirm miRNA targets.
  • Correlation analysis between miRNA levels, ABCA1, and cholesterol.

Main Results:

  • Elevated expression of miR-30e and miR-92a was observed in patients with coronary atherosclerosis.
  • ATP binding cassette (ABC)A1 was identified as a direct target of both miR-30e and miR-92a.
  • A negative correlation was found between plasma miR-30e and ABCA1, and between miR-30e and cholesterol levels.

Conclusions:

  • Serum exosomal miR-30e may serve as a novel diagnostic biomarker for coronary atherosclerosis.
  • The miR-30e/ABCA1 pathway is implicated in the development or progression of atherosclerosis.
  • Further validation is warranted to establish miR-30e as a reliable diagnostic tool for CAD.

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