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Related Experiment Videos

Developmental pattern for phosphatidylserine decarboxylase in rat brain.

F V White, A D Toews, P Morell

    Journal of Neurochemistry
    |April 1, 1986
    PubMed
    Summary

    Phosphatidylserine decarboxylase is crucial for synthesizing brain ethanolamine glycerophospholipids in rats. Its activity is relatively higher in early development compared to adulthood.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Developmental Biology

    Background:

    • Ethanolamine glycerophospholipids are vital brain components.
    • Phosphatidylserine decarboxylase is a key mitochondrial enzyme in their synthesis.

    Purpose of the Study:

    • To investigate the role of phosphatidylserine decarboxylase during rat brain development.
    • To compare its activity with another mitochondrial enzyme, succinate dehydrogenase.

    Main Methods:

    • Enzyme activity assays (phosphatidylserine decarboxylase, succinate dehydrogenase) in rat brain homogenates from postnatal day 5 to adulthood.
    • In vivo studies using radiolabeled precursors (L-[G-3H]serine and [2-14C]ethanolamine) to assess pathway contributions.

    Main Results:

    • Succinate dehydrogenase activity increased with development, as expected.
    • Phosphatidylserine decarboxylase activity decreased by 40% from 5 to 30 days of age.
    • In vivo, the contribution of the phosphatidylserine decarboxylase pathway decreased by 50% during development.

    Conclusions:

    • Phosphatidylserine decarboxylase plays a significant role in brain ethanolamine glycerophospholipid synthesis across all ages.
    • This enzyme's relative importance is greater during early brain development.

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