Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imprinting01:22

Imprinting

11.1K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
11.1K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.1K
Solution Composition During Acid/Base Titrations01:17

Solution Composition During Acid/Base Titrations

1.6K
The titration of a weak acid with a strong base results in the formation of water and the conjugate base of the acid. For instance, titrating acetic acid with sodium hydroxide leads to the formation of water and sodium acetate. A solution of acetic acid and sodium acetate constitutes a buffer whose relative concentration at different stages of the titration is indicated by the α values, which represent percentages of the weak acid and its conjugate base.
The α0 and α1 values...
1.6K
Classifying Matter by Composition03:35

Classifying Matter by Composition

90.2K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.2K
Conduction System of the Heart01:19

Conduction System of the Heart

13.2K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.2K
Conduction System of the Heart01:20

Conduction System of the Heart

3.7K
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezoelectric PCL/PVDF core-shell nanofibrous scaffolds for enhanced osteogenesis under dynamic loading.

Biomaterials advances·2026
Same author

Cell-imprinted substrates as biomimetic platforms for osteoarthritis modeling with mesenchymal stem cells.

BioImpacts : BI·2026
Same author

Investigation of nanoscale topography and biomechanical tuning of PDMS substrates to enhance cardiomyocyte differentiation from human induced pluripotent stem cells.

Biomaterials science·2026
Same author

A cell-laden methacrylated chitosan-based photocrosslinkable hydrogel for bone tissue engineering and its in vitro structural and biological characterization.

Scientific reports·2026
Same author

Wound healing improvement by a multicomponent wound dressing of keratinocyte-imprinted polydimethylsiloxane substrate in a rabbit model.

Scientific reports·2025
Same author

Integrated microoptical system for continuous fluorescence monitoring of microtissues.

Microsystems & nanoengineering·2025
Same journal

Development and Validation of an ELISA Method for Quantification of HuB01 in Fermentation Products.

Biotechnology and applied biochemistry·2026
Same journal

Optimization and Characterization of Poly-γ-Glutamic Acid Production From a Locally Isolated Bacillus cereus ARM24.

Biotechnology and applied biochemistry·2026
Same journal

Isolation and Characterization of a Novel Microbacterium takaoensis Lipase for Nutritional and Textural Improvement of Pizza Dough.

Biotechnology and applied biochemistry·2026
Same journal

Targeting Amastigote and Trypomastigote Phases: Multi-Epitope Vaccine Strategy Against Trypanosoma cruzi.

Biotechnology and applied biochemistry·2026
Same journal

Novel Inhibitors Targeting Class B1 Metallo-β-Lactamases in Carbapenem-Resistant Acinetobacter baumannii.

Biotechnology and applied biochemistry·2026
Same journal

Formulation of PLA/Chitosan Copolymeric Nanocarriers Enhanced the Sustained and Targeted Drug Delivery of Cinnamic Acid: In Vitro Drug Optimization and In Vivo Biodistribution in Rat Model.

Biotechnology and applied biochemistry·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Stretching Micropatterned Cells on a PDMS Membrane
09:41

Stretching Micropatterned Cells on a PDMS Membrane

Published on: January 22, 2014

15.9K

A conductive cell-imprinted substrate based on CNT-PDMS composite.

Hanie Kavand1, Mahdi Rahaie1, Javad Koohsorkhi2

  • 1Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.

Biotechnology and Applied Biochemistry
|March 1, 2019
PubMed
Summary
This summary is machine-generated.

This study presents a new biocompatible substrate for tissue engineering that mimics the natural cell environment. The conductive composite material enhances cell adhesion, improving the efficiency of tissue regeneration processes.

Keywords:
bioengineeringbiomimeticelastomersnanotubes

More Related Videos

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

3.3K
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

12.6K

Related Experiment Videos

Last Updated: Jan 28, 2026

Stretching Micropatterned Cells on a PDMS Membrane
09:41

Stretching Micropatterned Cells on a PDMS Membrane

Published on: January 22, 2014

15.9K
Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

3.3K
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

12.6K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Cell function is regulated by biochemical and biophysical signals.
  • Nano/micro-scaled substrates mimicking physiological niches are crucial for tissue engineering.
  • Cartilage tissue engineering requires multifunctional substrates with topographical and electrical stimulation capabilities.

Purpose of the Study:

  • To develop a multifunctional substrate for cartilage tissue engineering.
  • To create a biocompatible and conductive cell-imprinted substrate using polydimethylsiloxane (PDMS) and carbon nanotubes (CNTs).
  • To address challenges in replicating cell surface topography without chemical solvent residues.

Main Methods:

  • Fabrication of a composite substrate using PDMS and CNTs.
  • Cell surface topographical replication using a novel molding technique.
  • Assessment of substrate cytotoxicity and cell adhesion properties.

Main Results:

  • The PDMS/CNT composite demonstrated no significant difference in cytotoxicity compared to pure PDMS.
  • Enhanced cell adhesion was observed on the conductive composite surface.
  • Successful replication of chondrocyte cell topography was achieved.

Conclusions:

  • The developed substrate is biocompatible and conductive, suitable for tissue engineering applications.
  • Integration of nanomaterials like CNTs into scaffolds improves cell adhesion and tissue regeneration efficiency.
  • This approach offers a promising strategy for creating advanced cell-imprinted scaffolds.