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Asthma-I: Introduction01:29

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Related Experiment Video

Updated: Jan 28, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Severe asthma-A population study perspective.

Helena Backman1, Sven-Arne Jansson1, Caroline Stridsman2

  • 1Section of Sustainable Health, The OLIN Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|March 1, 2019
PubMed
Summary
This summary is machine-generated.

Severe asthma affects approximately 0.5% of the general population. This study found prevalence rates of 4%-6% in an adult asthma cohort, identifying key characteristics and inflammatory markers for better treatment strategies.

Keywords:
IgEasthmaeosinophilsepidemiologylung functionneutrophils

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Area of Science:

  • Pulmonology
  • Epidemiology
  • Clinical Medicine

Background:

  • Severe asthma presents significant challenges for patients and healthcare systems.
  • Existing research lacks prevalence data based on modern definitions from population studies.

Purpose of the Study:

  • To determine the prevalence and characteristics of severe asthma in a large, adult, population-based cohort.
  • To compare severe asthma prevalence using three major international definitions.

Main Methods:

  • A cohort of 1006 asthma patients was followed for 10-28 years, with 830 having current asthma at follow-up.
  • Severe asthma was defined using the US SARP (2000), ATS/ERS Taskforce (2014), and GINA (2017) criteria.
  • Treatment adherence and specialist care were verified for all severe asthma cases.

Main Results:

  • Prevalence of severe asthma was 3.6% (US SARP), 4.8% (ERS/ATS), and 6.1% (GINA).
  • Over 90% of severe asthma patients had uncontrolled asthma despite high-dose medication.
  • Severe asthma was associated with older age, nasal polyposis, reduced lung function, Aspergillus sensitization, and higher blood neutrophils.

Conclusions:

  • Severe asthma exhibits distinct demographic, clinical, and inflammatory profiles compared to other asthma types.
  • Findings suggest potential for improved treatment strategies for severe asthma.
  • The prevalence in the general population is estimated at 0.5%, with cohort prevalence at 4%-6%.