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Published on: October 10, 2018
Electrochemically Promoted Fluoroalkylation-Distal Functionalization of Unactivated Alkenes
Zhenlei Zou1, Weigang Zhang1, Yang Wang1
1Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering , Nanjing University , 163 Xianlin Avenue , 210023 Nanjing , China.
Abstract:
Difunctionalization of olefins represents a powerful synthetic tool and yet a challenging task. This work describes an electrochemically enabled fluoroalkylation-migration reaction of unactivated olefins in the absence of a strong oxidant or heavy metal catalyst, affording fluorinated (hetero)aryl ketones in good yields and excellent regioselectivities. The efficient and sustainable electrochemical strategy provides a rapid access to a dual functionalized fluorine-containing heterocyclic manifold.
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