Related Experiment Video

Updated: Jan 28, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

Interplay between the androgen receptor signaling axis and microRNAs in prostate cancer

Rayzel C Fernandes1,2, Theresa E Hickey1, Wayne D Tilley1,2

  • 1Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

Endocrine-Related Cancer
|March 1, 2019
PubMed

Insights

MicroRNAs (miRNAs) regulate androgen receptor (AR) signaling, impacting prostate cancer progression and treatment resistance. Understanding this interplay is key for developing novel miRNA-based therapies for hormone-driven prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Androgen receptor (AR) signaling drives prostate cancer growth and metastasis.
  • Current therapies targeting AR are crucial for metastatic prostate cancer treatment.
  • MicroRNAs (miRNAs) are key regulators in prostate cancer, influencing AR signaling.

Purpose of the Study:

  • To review the bidirectional regulation between AR signaling and miRNAs in prostate cancer.
  • To discuss how this miRNA-AR axis impacts cancer growth, metastasis, and therapy resistance.
  • To explore the clinical potential of miRNAs targeting AR signaling.

Main Methods:

  • Literature review of studies on AR signaling and miRNAs in prostate cancer.
  • Analysis of miRNA-mediated regulation of AR.
  • Examination of AR-mediated regulation of miRNAs.
  • Synthesis of findings on clinical implications.

Main Results:

  • miRNAs significantly modulate AR signaling pathways in prostate cancer.
  • AR signaling influences the expression and function of specific miRNAs.
  • This complex interplay affects tumor progression and the development of resistance to anti-androgen therapies.
  • Several miRNAs show potential as therapeutic targets or biomarkers.

Conclusions:

  • The intricate relationship between miRNAs and AR signaling is a critical determinant of prostate cancer behavior.
  • Targeting this axis offers promising avenues for novel therapeutic strategies.
  • Further research into miRNA-AR interactions could lead to improved treatments for hormone-driven prostate cancer.
Keywords:
androgen receptorbiomarkersmicroRNAprostate cancertherapy

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.2K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
Signal Sequences and Sorting Receptors01:41

Signal Sequences and Sorting Receptors

Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...
15.3K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
3.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K